Sunday, February 23, 2025
HomeHealthPrevalence of gram-negative micro organism and their antibiotic resistance in neonatal sepsis...

Prevalence of gram-negative micro organism and their antibiotic resistance in neonatal sepsis in Iran: a scientific evaluation and meta-analysis | BMC Infectious Diseases


  • Amuka JI, Asogwa FO, Ugwuanyi RO, Onyechi T. Neonatal deaths and challenges of public well being: the place do we want pressing intervention in growing international locations? Health Care Women Int. 2020;41(2):227–37.

    PubMed 

    Google Scholar 

  • Randolph AG, McCulloh RJ. Pediatric sepsis: essential issues for diagnosing and managing extreme infections in infants, kids, and adolescents. Virulence. 2014;5(1):179–89.

    PubMed 

    Google Scholar 

  • Tsai MH, Wu IH, Lee CW, Chu SM, Lien R, Huang HR, Chiang MC, Fu RH, Hsu JF, Huang YC. Neonatal gram-negative bacillary late-onset sepsis: a case-control-control examine on a prospectively collected database of 5,233 admissions. Am J Infect Control. 2016;44(2):146–53.

    PubMed 

    Google Scholar 

  • World Health O. Global motion plan on antimicrobial resistance. Geneva: World Health Organization; 2015.

    Google Scholar 

  • Wen SCH, Ezure Y, Rolley L, Spurling G, Lau CL, Riaz S, Paterson DL, Irwin AD. Gram-negative neonatal sepsis in low- and lower-middle-income international locations and WHO empirical antibiotic suggestions: a scientific evaluation and meta-analysis. PLoS Med. 2021;18(9): e1003787.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Schlapbach LJ, Straney L, Alexander J, MacLaren G, Festa M, Schibler A, Slater A. Mortality associated to invasive infections, sepsis, and septic shock in critically unwell kids in Australia and New Zealand, 2002–13: a multicentre retrospective cohort examine. Lancet Infect Dis. 2015;15(1):46–54.

    PubMed 

    Google Scholar 

  • Laxminarayan R, Matsoso P, Pant S, Brower C, Røttingen JA, Klugman Ok, Davies S. Access to efficient antimicrobials: a worldwide problem. Lancet (London, England). 2016;387(10014):168–75.

    PubMed 

    Google Scholar 

  • Akbarian-Rad Z, Riahi SM, Abdollahi A, Sabbagh P, Ebrahimpour S, Javanian M, Vasigala V, Rostami A. Neonatal sepsis in Iran: a scientific evaluation and meta-analysis on nationwide prevalence and causative pathogens. PLoS One. 2020;15(1): e0227570.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Akya A, Rostamian M, Rezaeian S, Ahmadi M, Janatolmakan M, Sharif SA, Ahmadi A, Weisi S, Chegene Lorestani R. Bacterial causative brokers of neonatal sepsis and their antibiotic susceptibility in Neonatal Intensive Care Units (NICUs) and Neonatal Wards in Iran: a Systematic Review. Arch Pediatr Infect Dis. 2020;8(2): e92212.

    Google Scholar 

  • Moftian N, Samad Soltani T, Mirnia Ok, Esfandiari A, Tabib MS, Rezaei Hachesu P. Clinical danger elements for early-onset sepsis in neonates: a world delphi examine. Iran J Med Sci. 2023;48(1):57–69.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Fahimzad A, Eydian Z, Karimi A, Shiva F, Armin S, Mansour Ghanaei R, Fallah F, Rafiei Tabatabaei S, Shirvani F, Rahbar M, et al. Antibiotic prescribing sample in neonates of seventeen Iranian Hospitals. Arch Pediatr Infect Dis. 2017;5(4): e61630.

    Google Scholar 

  • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting gadgets for systematic critiques and meta-analyses: the PRISMA assertion. PLoS Med. 2009;6(7): e1000097.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Porritt Ok, Gomersall J, Lockwood C. JBI’s systematic critiques: examine choice and demanding appraisal. Am J Nurs. 2014;114(6):47–52.

    PubMed 

    Google Scholar 

  • Karambin M, Zarkesh M. Entrobacter, the commonest pathogen of neonatal septicemia in rasht, iran. Iran J Pediatr. 2011;21(1):83–7.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Fatehi T, Anvari M, Ranji N. Investigating antibiotic resistance and the frequency of SHVand TEM Extended Expecterum Beta Lactamase Genes in klebsiella penumoniea Isolated from Blood Samples of Neonates Admitted to Some Health Centers in Rasht. Iran J Med Microbiol. 2017;11(4):57–63.

    Google Scholar 

  • Rafati MR, Farhadi R, Nemati-Hevelai E, Chabra A. Determination of frequency and antibiotic resistance of frequent micro organism in late onset sepsis on the neonatal ward in Booali-Sina Hospital of Sari. Iran J Babol Univ Med Sci. 2014;16(6):64–71.

    Google Scholar 

  • Mozafari A, Asghari F, Hosseini S. Bacterial etiology and antibiotic resistance of neonotal sepsis. Med J Tabriz Uni Med Sciences Health Services. 2006;27(4):107–10.

    Google Scholar 

  • Shahian M, Pishva N, Kalani M. Bacterial etiology and antibiotic sensitivity patterns of early-late onset neonatal sepsis amongst Newborns in Shiraz, Iran 2004–2007. Iran J Med Sci. 2010;35(4):293–8.

    Google Scholar 

  • Sedigh Ebrahim-Saraie H, Motamedifar M, Mansury D, Halaji M, Hashemizadeh Z, Ali-Mohammadi Y. Bacterial etiology and antibacterial susceptibility patterns of pediatric bloodstream infections: a two 12 months examine from Nemazee Hospital, Shiraz. Iran J Compr Ped. 2016;7(1): e29929.

    Google Scholar 

  • Rezaei A, Javanmardi F, Pirbonyeh N, Parsa HR, Eskandari kootahi z, Emami A: prevalence and antibiotic susceptibility of escherichia coli remoted from early-onset sepsis in Shiraz, Iran. Infec Epidemiol Microbiol. 2021; 7(4):305-310

  • Behmadi H, Borji A, Taghavi-Rad A, Soghandi L, Behmadi R. Prevalence and antibiotic resistance of neonatal sepsis pathogens in neyshabour. Iran Arch Pediatr Infect Dis. 2016;4(2): e33818.

    Google Scholar 

  • Mohammadi N, Gharebaghi M, Maamuri GA. Determination of bacterial causes of sepsis in untimely newborns. Med J Tabriz Uni Med Sciences Health Services. 2007;29(4):67–71.

    Google Scholar 

  • Boskabadi H, Heidari E, Bagheri F, Zakerihamidi M. Antibiotic susceptibility patterns within the NICU of Ghaem Hospital of Mashhad. Int J Med Lab. 2021;8(1):17–26.

    Google Scholar 

  • Falahi J, Khaledi A, Esmaeili D, Ghazvini Ok, Rostami H. Prevalence and varieties of micro organism related to neonatal sepsis in neonatal ward from Ghaem hospital of Mashhad. Iran Der Pharmacia Lettre. 2016;8(3):240–5.

    Google Scholar 

  • Aletayeb SMH, Khosravi AD, Dehdashtian M, Kompani F, Mortazavi SM, Aramesh MR. Identification of bacterial brokers and antimicrobial susceptibility of neonatal sepsis: A 54-month examine in a tertiary hospital. African J Microbiol Res. 2011;5(5):528–31.

    Google Scholar 

  • Monsef A, Eghbalian F. Antibiotic sensitivity sample of frequent bacterial pathogens in NICU and neonatal ward in Hamedan province of Iran. Health. 2010;2(06):625.

    Google Scholar 

  • Dezfoulimanesh Z, Tohidnia MR, Darabi F, Almasi A. Prevalence of bacterial and antibiotic sensitivity in septicemia of neonates admitted to Kermanshah Imam Reza Hospital (2007–2008). J Kermanshah Univ Med Sci. 2011;15(2): e79381.

    Google Scholar 

  • Nikkhoo B, Lahurpur F, Delpisheh A, Rasouli MA, Afkhamzadeh A. Neonatal blood stream infections in tertiary referral hospitals in Kurdistan Iran. Italian J Pediatr. 2015;41:43.

    Google Scholar 

  • Bahmani N. Bacterial etiology and antibiotic resistance patterns in neonatal sepsis within the West of Iran. Int J Pediatr. 2021;9(11):14737–46.

    CAS 

    Google Scholar 

  • Ghotaslou R, Ghorashi Z, Nahaei MR. Klebsiella pneumoniae in neonatal sepsis: a 3-year-study within the pediatric hospital of Tabriz Iran. Jap J Infect Dis. 2007;60(2–3):126–8.

    Google Scholar 

  • Mahallei M, Rezaee MA, Mehramuz B, Beheshtirooy S, Abdinia B. Clinical signs, laboratory, and microbial patterns of suspected neonatal sepsis instances in a kids’s referral hospital in northwestern Iran. Medicine. 2018;97(25): e10630.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Hosseini MB, Abdoli Oskouei S, Heidari F, Sadat Sharif A, Salimi Z, Sharif SAA. Determination of the frequency of microbial brokers and drug susceptibility sample of the neonatal sepsis within the neonatal intensive care unit at Alzahra Hospital, Tabriz Iran. Iran J Neonatol. 2019;10(4):33–40.

    CAS 

    Google Scholar 

  • Gheybi S, Fakour Z, Karamyar M, Khashabi J, Ilkhanizadeh B, Asghari Sana F, Mahmoudzadeh H, Majlesi AH. Coagulase damaging staphylococcus, the commonest reason behind neonatal septicemia in Urmia. Iran Iran J Pediatrics. 2008;18(3):237–43.

    Google Scholar 

  • Bakhsi khaniki G, Asgharisana F, Gaibi S. Study of the function of frequent bacterial etiology in neonatal sepsis in Urumiah Shahid arefian hospital. New Cellular Molecular Biotechnol J. 2011; 1(3):17–21.

  • Sharif MR, Hosseinian M, Moosavi GA, Sharif AR. Etiology of bacterial sepsis and bacterial drug resistance in hospitalized neonates of Shahid Beheshti Hospital of Kashan in 1375 and 1376. Feyz J Kashan Univ Med Sci. 2000;3(4):71–7.

    Google Scholar 

  • Malakan Rad E, Momtazmanesh N. Neonatal sepsis resulting from klebsiella: frequency, consequence and antibiotic sensitivity. Iran J Public Health. 2004;33(2):43–8.

    Google Scholar 

  • Movahedian A, Moniri R, Mosayebi Z. Bacterial tradition of neonatal sepsis. Iran J Public Health. 2006;35(4):84–9.

    Google Scholar 

  • Rajabi Z, Akbari N, Mardaneh J, Soltan DM. Antimicrobial susceptibility of remoted from neonatal blood and urine infections in neonatal intensive care unit (nicu), imam hossein hospital of tehran. J Microb Biotechnol. 2012;4(12):53–9.

    Google Scholar 

  • Behjati S. Reporting of antimicrobial susceptibility and microorganisms in neonatal sepsis in Children Medical Center Hospital. Tehran Univ Med J. 1998;56(2):22–4.

    Google Scholar 

  • Rabirad N, Mohammadpoor M, Lari AR, Shojaie A, Bayat R, Alebouyeh M. Antimicrobial susceptibility patterns of the gram-negative micro organism remoted from septicemia in Children’s Medical Center, Tehran Iran. J Prev Med Hygiene. 2014;55(1):23–6.

    CAS 

    Google Scholar 

  • Marzban A, Samaee H, Mosavinasab N. Changing pattern of empirical antibiotic routine: expertise of two research at completely different intervals in a neonatal intensive care unit in Tehran. Iran Acta Medica Iranica. 2010;48(5):312–5.

    PubMed 

    Google Scholar 

  • Haj Ebrahim Tehrani F, Moradi M, Ghorbani N. Bacterial etiology and antibiotic resistance patterns in neonatal sepsis in Tehran throughout 2006–2014. Iran J Pathol. 2017; 12(4):356–361.

  • Rajabi Z, Soltan Dallal MM. Study on bacterial strains inflicting blood and urinary tract infections within the neonatal intensive care unit and willpower of their antibiotic resistance sample. Jundishapur J Microbiol. 2015;8(8): e19654.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Mahmoudi S, Mahzari M, Banar M, Pourakbari B, Haghi Ashtiani MT, Mohammadi M, Keshavarz Valian S, Mamishi S. Antimicrobial resistance patterns of Gram-negative micro organism remoted from bloodstream infections in an Iranian referral paediatric hospital: a 5.5-year examine. J Glob Antimicrob Resist. 2017; 11:17–22.

  • Almohammady MN, Eltahlawy EM, Reda NM. Pattern of bacterial profile and antibiotic susceptibility amongst neonatal sepsis instances at Cairo University Children Hospital. J Taibah Univ Med Sci. 2020;15(1):39–47.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Peterside O, Pondei Ok, Akinbami FO. Bacteriological profile and antibiotic susceptibility sample of neonatal sepsis at a Teaching Hospital in Bayelsa State. Nigeria Trop Med Health. 2015;43(3):183–90.

    PubMed 

    Google Scholar 

  • Shehab El-Din EMR, El-Sokkary MMA, Bassiouny MR, Hassan R. Epidemiology of neonatal sepsis and implicated pathogens: a examine from Egypt. Biomed Res Int. 2015;2015: 509484.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Le Doare Ok, Bielicki J, Heath PT, Sharland M. Systematic evaluation of antibiotic resistance charges amongst Gram-negative micro organism in kids with sepsis in resource-limited international locations. J Pediatr Infect Dis Soc. 2015;4(1):11–20.

    Google Scholar 

  • Zelellw DA, Dessie G, Worku Mengesha E, Balew Shiferaw M, Mela Merhaba M, Emishaw S. A systemic evaluation and meta-analysis of the main pathogens inflicting neonatal sepsis in growing international locations. Biomed Res Int. 2021;2021:6626983.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Azami M, Jaafari Z, Masoumi M, Shohani M, Badfar G, Mahmudi L, Abbasalizadeh S. The etiology and prevalence of urinary tract an infection and asymptomatic bacteriuria in pregnant ladies in Iran: a scientific evaluation and Meta-analysis. BMC Urol. 2019;19(1):43.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Gajul SV, Mohite ST, Mangalgi SS, Wavare SM, Kakade SV. Klebsiella Pneumoniae in septicemic neonates with particular reference to prolonged spectrum β-lactamase, AmpC, Metallo β-lactamase manufacturing and a number of drug resistance in tertiary care hospital. J Lab Phys. 2015;7(1):32–7.

    CAS 

    Google Scholar 

  • Mukherjee S, Mitra S, Dutta S, Basu S. Neonatal sepsis: the affect of carbapenem-resistant and hypervirulent Klebsiella pneumoniae. Front Med. 2021;8: 634349.

    Google Scholar 

  • You T, Zhang H, Guo L, Ling KR, Hu XY, Li LQ. Differences in scientific traits of early- and late-onset neonatal sepsis brought on by Klebsiella pneumoniae. Int J Immunopathol Pharmacol. 2020;34:2058738420950586.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • World Health O: Pocket guide of hospital care for youngsters: tips for the administration of frequent childhood diseases, 2nd ed. edn. Geneva: World Health Organization; 2013.

  • Versporten A, Bielicki J, Drapier N, Sharland M, Goossens H. The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) level prevalence survey: growing hospital-quality indicators of antibiotic prescribing for youngsters. J Antimicrob Chemother. 2016;71(4):1106–17.

    CAS 
    PubMed 

    Google Scholar 

  • Majigo M, Makupa J, Mwazyunga Z, Luoga A, Kisinga J, Mwamkoa B, Kim S, Joachim A. Bacterial aetiology of neonatal sepsis and antimicrobial resistance sample on the regional referral Hospital, Dar es Salam, Tanzania; a name to strengthening antibiotic stewardship program. Antibiotics (Basel, Switzerland). 2023;12(4):767.

  • Akturk H, Sutcu M, Somer A, Aydın D, Cihan R, Ozdemir A, Coban A, Ince Z, Citak A, Salman N. Carbapenem-resistant Klebsiella pneumoniae colonization in pediatric and neonatal intensive care items: danger elements for development to an infection. Braz J Infect Dis. 2016;20(2):134–40.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Nour I, Eldegla HE, Nasef N, Shouman B, Abdel-Hady H, Shabaan AE. Risk elements and scientific outcomes for carbapenem-resistant Gram-negative late-onset sepsis in a neonatal intensive care unit. J Hosp Infect. 2017;97(1):52–8.

    CAS 
    PubMed 

    Google Scholar 

  • Ding Y, Wang Y, Hsia Y, Sharland M, Heath PT. Systematic evaluation of carbapenem-resistant Enterobacteriaceae inflicting neonatal sepsis in China. Ann Clin Microbiol Antimicrob. 2019;18(1):36.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Okomo U, Akpalu ENK, Le Doare Ok, Roca A, Cousens S, Jarde A, Sharland M, Kampmann B, Lawn JE. Aetiology of invasive bacterial an infection and antimicrobial resistance in neonates in sub-Saharan Africa: a scientific evaluation and meta-analysis consistent with the STROBE-NI reporting tips. Lancet Infect Dis. 2019;19(11):1219–34.

    CAS 
    PubMed 

    Google Scholar 

  • Patel SJ, Green N, Clock SA, Paul DA, Perlman JM, Zaoutis T, Ferng YH, Alba L, Jia H, Larson EL, et al. Gram-Negative bacilli in infants hospitalized within the neonatal intensive care unit. J Pediatr Infect Dis Soc. 2017;6(3):227–30.

    Google Scholar 

  • Tessema B, Lippmann N, Knüpfer M, Sack U, König B. Antibiotic resistance patterns of bacterial isolates from neonatal sepsis sufferers at University Hospital of Leipzig, Germany. Antibiotics (Basel, Switzerland). 2021;10(3):323.

  • Li JY, Chen SQ, Yan YY, Hu YY, Wei J, Wu QP, Lin ZL, Lin J. Identification and antimicrobial resistance of pathogens in neonatal septicemia in China-A meta-analysis. Int J Infect Dis. 2018;71:89–93.

    CAS 
    PubMed 

    Google Scholar 

  • Flannery DD, Akinboyo IC, Mukhopadhyay S, Tribble AC, Song L, Chen F, Li Y, Gerber JS, Puopolo KM. Antibiotic susceptibility of escherichia coli amongst infants admitted to neonatal intensive care items throughout the US From 2009 to 2017. JAMA Pediatr. 2021;175(2):168–75.

    PubMed 

    Google Scholar 

  • Stoll BJ, Puopolo KM, Hansen NI, Sánchez PJ, Bell EF, Carlo WA, Cotten CM, D’Angio CT, Kazzi SNJ, Poindexter BB, et al. Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies. JAMA Pediatr. 2020;174(7): e200593.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Google Scholar 

  • Hayati M, Indrawati A, Mayasari N, Istiyaningsih I, Atikah N. Molecular detection of extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolates of hen origin from East Java, Indonesia. Vet World. 2019;12(4):578–83.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Padmini N, Ajilda AAK, Sivakumar N, Selvakumar G. Extended spectrum β-lactamase producing Escherichia coli and Klebsiella pneumoniae: important instruments for antibiotic resistance sample. J Basic Microbiol. 2017;57(6):460–70.

    CAS 
    PubMed 

    Google Scholar 

  • Lowings M, Ehlers MM, Dreyer AW, Kock MM. High prevalence of oxacillinases in scientific multidrug-resistant Acinetobacter baumannii isolates from the Tshwane area, South Africa – an replace. BMC Infect Dis. 2015;15:521.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Pacifici G, Marchini G. Clinical pharmacology of cefotaxime in neonates and infants: results and pharmacokinetics. Int J Pediatr. 2017;5(11):6111–38.

    CAS 

    Google Scholar 

  • Cantey JB, Patel SJ. Antimicrobial stewardship within the NICU. Infect Dis Clin North Am. 2014;28(2):247–61.

    PubMed 

    Google Scholar 

  • Nzegwu NI, Rychalsky MR, Nallu LA, Song X, Deng Y, Natusch AM, Baltimore RS, Paci GR, Bizzarro MJ. Implementation of an Antimicrobial Stewardship Program in a Neonatal Intensive Care Unit. Infect Control Hosp Epidemiol. 2017;38(10):1137–43.

    PubMed 

    Google Scholar 

  • Chandel DS, Johnson JA, Chaudhry R, Sharma N, Shinkre N, Parida S, Misra PR, Panigrahi P. Extended-spectrum beta-lactamase-producing Gram-negative micro organism inflicting neonatal sepsis in India in rural and concrete settings. J Med Microbiol. 2011;60(Pt 4):500–7.

    PubMed 
    PubMed Central 

    Google Scholar 



  • Source hyperlink

    RELATED ARTICLES

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    This site uses Akismet to reduce spam. Learn how your comment data is processed.

    Most Popular