Semaglutide medication similar to Ozempic and Wegovy have exploded in recognition lately attributable to their effectiveness in diabetes management and weight reduction.
Research has revealed extra advantages past these main makes use of, however some destructive unintended effects have additionally emerged.
Gastrointestinal issues are the most typical aspect impact, however a current research by the University of British Columbia discovered that GLP-1 (glucagon-like peptide-1) agonists (a category of medicine containing semaglutide) have been related to elevated threat of hair loss.
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The researchers analyzed information from 16 million sufferers from the well being claims database and narrowed it right down to 1,926 semaglutide customers and 1,348 customers Bupropion-Naltrexone.
A current research by the University of British Columbia has related GLP-1 (glucagon-like peptide-1) agonists (a category of medicine containing semaglutide) with elevated hair loss threat. (istock)
After adjusting for different components, they discovered that semaglutide customers have been total 50% extra more likely to expertise hair loss in comparison with different teams.
Women have been extra more likely to have this end result, at twice the chance of males.
“Not stunned.”
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Dr. Patrick Davis, a plastic surgeon and hair restore skilled at Beverly Hills, agreed that the findings weren’t shocking.
After adjusting for different components, the researchers discovered that customers of semaglutide have been 50% extra more likely to expertise hair loss in comparison with different teams. (istock)
“Hair development (and loss) is closely depending on components like weight loss plan, important nutritional vitamins, bodily stress, and genetics.”
The first three components come up throughout weight reduction, he identified — “And semaglutide-driven loss might be no exception.”
Previous research have proven that inducing stress and affecting dietary consumption can improve the chance of hair loss.
“Hair development (and loss) is closely depending on components like weight loss plan, important nutritional vitamins, bodily stress, and genetics.”
“The research notes that individuals who lose greater than 20% of their physique weight have the next price of hair loss than those that do not,” Davis identified.
“The research theorizes that this can be attributable to suspected physiological stress, which might be a symptom of such fast weight reduction.”
He stated long-term hair loss isn’t very possible, as “stimulating occasions” (weight reduction and stress) are sometimes normalized when reaching the goal’s weight.
Potential limitations
The research had a number of limitations, famous researcher Etominan.
They included the truth that hair elimination couldn’t be verified by way of medical information, however solely the medical code for hair elimination might be recognized.
Women have been extra more likely to expertise semaglutide-related hair loss at twice the chance of males. (istock)
Plastic surgeon Davis additionally famous that on this research, Wegovy customers refer to a different research the place hair loss threat (3.3%) was elevated in comparison with the placebo group (1.4%).
“This clearly signifies an elevated threat, however 3.3% continues to be a really low incidence,” he stated.
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This early research revealed in Preprint Server MedRXIV has not but been peer-reviewed.
“Future analysis is required to substantiate the affiliation between semaglutide and hair loss,” the researchers wrote.
Doctor’s recommendation
Anyone who has skilled hair loss whereas taking semaglutide medicine ought to seek the advice of with a dermatologist to find out whether or not the hostile results of those medicines are the trigger, Etominan suggested.
“This is a comparatively new hostile occasion and never a lot is understood about it,” he stated. “Questions about who’s on the most threat and whether or not future analysis will reverse hair loss when medication are stopped.”
Davis agreed and inspired sufferers to have an open dialog with their physician about how greatest to look after them.
“I feel sufferers ought to think about potential unintended effects earlier than taking the medicine,” he stated.
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“While the incidence of hair loss continues to be clearly low, it’s a potential trade-off that sufferers ought to think about.”
Davis additionally recommends that sufferers undertake a “heartful weight loss plan” consisting of fiber, protein and nutritious meals to make sure correct diet whereas taking semaglutide medicines.
Experts suggested that anybody who has skilled hair loss whereas taking semaglutide medicine ought to seek the advice of with a dermatologist to find out whether or not the hostile results of those medicines are the trigger. (istock)
“This not solely helps with hair elimination, however extra importantly, it might probably management the pointless lack of muscle mass {that a} sturdy weight loss plan usually causes,” he stated. “A correct weight loss plan, a conservative timetable for weight reduction, and an train plan are important when taking this medicine.”
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“In Wegovy’s scientific trial, hair loss was reported in 1.0% of grownup sufferers handled with Wegovy, in comparison with 2.5% of grownup sufferers handled with Wegovy,” a spokesman for the corporate stated.
“While the incidence of hair loss continues to be clearly low, it’s a potential trade-off that sufferers ought to think about.”
“Hair loss is reported extra incessantly in sufferers with giant weight reduction (>20%), suggesting that hair loss occasions are probably associated to the magnitude of weight reduction.”
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The research was funded by an inside analysis fund from the Faculty of Ophthalmology and Visual Sciences on the University of British Columbia, the journal article states.