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Weight loss surgical procedure was proven to be 5 occasions more practical than weekly injections of widespread GLP-1 receptor agonists, together with semaglutide (e.g. ozenpic) and tilzepatide (e.g. munjaro).
The discovery comes from a current research introduced this week on the American Society for Metabolic and Bariatric Surgery (ASMBS) 2025 Annual Science Conference held in Washington.
The researchers checked out “actual world” digital medical file information for 51,085 sufferers from NYU Langone Health and NYC Health + Hospitals.
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All sufferers had a physique mass index (BMI) of at the very least 35.
They both had bariatric surgical procedure (sleeve gastrectomy or Luen Y gastric bypass) or had been prescribed injectable semaglutide or tilzepatide between 2018 and 2024.
Weight loss surgical procedure was proven to be 5 occasions more practical than weekly injections of widespread GLP-1 receptor agonists. (istock)
(Sleeve gastrectomy reduces the dimensions of the abdomen to assist overweight sufferers drop extra pounds. Gastric bypass entails re-routing components of the gastrointestinal tract to bypass components of the small gut, in response to the mayonnaise clinic.)
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Those who took GLP-1 medicine all 12 months spherical confirmed extra weight reduction (7%), however that was nonetheless lower than those that obtained one of many surgical procedures.
These outcomes differ from these from scientific trials.
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“Participants with GLP-1 might have to regulate their expectations, stick extra carefully to therapy, or select metabolic and bariatric surgical procedure to attain the specified end result,” he suggested.
Surgical outcomes marked whole weight lack of 24% in comparison with 4.7% of injectable medication.
In future analysis, researchers plan to discover methods to enhance outcomes in sufferers taking GLP-1 and determine which sufferers are higher candidates for injections and injections, Release mentioned.
The prevalence of GLP-1 medication is increased than that of bariatric surgical procedure. Studies present that round 12% of Americans take GLP-1, whereas 6% are at present accumulating them.
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However, greater than half of sufferers stopped taking them after a 12 months, and 72% deserted them after two years, research discovered.
According to ASMBS, solely about 1% of sufferers who met the factors for metabolic and bariatric surgical procedure obtained certainly one of these procedures in 2023.
Only about 1% of sufferers assembly metabolic and bariatric surgical procedure standards obtained a kind of procedures in 2023 (AP Photo/Kirsty Wigglesworth, file)
The research obtained a grant from the National Center for Advancement of Translational Science on the National Institutes of Health (NIH).
Novo Nordisk, the maker of Ozempic and Wegovy, declined to request remark.
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